Two minor problems occurred during the flight. The orbiter sustained only minor Space Shuttle thermal protection system tile damage, and the redesigned post- Challenger solid rocket boosters showed no signs of leakage or overheating at any of the joints. The primary payload for the STS-26 mission, TDRS-C, was successfully deployed, and 11 scheduled mid-deck scientific and technological experiments were carried out. The shuttle crew, all veteran astronauts, included Commander Frederick H. It was quickly determined that the cabin pressure had been increased slightly by the activation of the oxygen systems in the crew's flight suits, and the launch was conducted without further delay. At T-1:30, it was proposed that the launch be delayed at T-0:31 due to a cabin air pressure issue. The suits were repaired, and a waiver was issued for the wind conditions after officials determined there was a sufficient safety margin for wind loads on the orbiter's wing leading edges. The launch was delayed by one hour and thirty-eight minutes due to unseasonable and unusual light winds, and the need to replace fuses in the cooling systems of two crew members' flight suits. EDT on September 29, 1988, 975 days after the Challenger disaster. Space Shuttle Discovery lifted off from Launch Complex 39B, Kennedy Space Center, at 11:37:00 a.m. He also would have been the CAPCOM operator for the canceled STS-61-F mission during launch and landing.ĭiscovery lifts off from KSC, the first shuttle mission after the Challenger disaster Bridges never flew again after the Challenger disaster, but would eventually become the director of Langley Research Center (LRC).Ĭovey was the CAPCOM operator during the STS-51-L launch who uttered the words, " Challenger, go at throttle up", shortly after which the orbiter disintegrated. Hauck, Lounge and Hilmers were all assigned to that flight, with Roy D. Ulysses was eventually launched on STS-41. The crew roster for STS-26 was based on the original crew assignment for STS-61-F, which would have launched the Ulysses probe from Challenger in 1986. Likewise all flights with the STS-26 through STS-33 designations would require the R in their documentation to avoid conflicts in tracking data between the old and new flight designations. The mission is technically designated STS-26R, as the original STS-26 designation previously belonged to STS-51-F (also known as Spacelab-2). space mission with an all-veteran crew since Apollo 11, with all of its crew members having flown at least one prior mission. It was the first mission since STS-9 to use the original Space Transportation System (STS) numbering system, the first to have all its crew members wear pressure suits for launch and landing since STS-4, and the first mission with bailout capacity since STS-4. STS-26 was declared the "Return to Flight" mission, being the first mission after the Space Shuttle Challenger disaster of January 28, 1986. The mission launched from Kennedy Space Center, Florida, on September 29, 1988, and landed four days later on October 3, 1988. STS-26 was the 26th NASA Space Shuttle mission and the seventh flight of the orbiter Discovery.
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The Rundown stars Dwayne “The Rock” Johnson who plays Beck, a tight-lipped bounty hunter who doesn’t like guns and will accept any job. Talk about a lifesaver! Eventually, the two men re-team to locate $20,000 that a soldier buried in the desert however, they must beat out a nasty criminal and the Union army to get it. Joe turns in the bandit for the reward money, only to rescue him just as he’s being hanged. Set in the Southwest during the Civil War, a mysterious stranger, Joe (Clint Eastwood), and a Mexican bandit, Tuco (Eli Wallach), form an uneasy alliance. Now that’s what we call Earth-shattering treasure! 17) The Good, The Bad and the Ugly (1966) The map leads him on an adventure to find the “Titan,” which isn’t quite your typical silver and gold treasure…it’s a ship that has the power to create planets like our own. The story follows Cale (Matt Damon), a human teenager, who has been given a mysterious map by his father. takes place in the future after Earth has been destroyed by a mysterious alien race known as the Drej. (2000)Ī science-fiction film that combines traditional animation with computer generated images, Titan A.E. We wont spoil anything, but let’s just say Mother Nature knows best… 18) Titan A.E. Years later, Mowgli discovers Monkey City, is reunited with his childhood friend, Kitty (Lena Headey), and crosses paths with her ruthless suitor Captain Boone (Cary Elwes), who will stop at nothing to steal the treasures of Monkey City. He grows up in the wild, meeting Bagheera, Baloo, and the rest of Rudyard Kipling’s gang of animals. However, in this version, Mowgli (Jason Scott Lee) is left orphaned after his father is killed by a jungle tiger (Shere Khan). Next we have a movie that has been made several times, with the most recent iteration having been released a few months back. Perhaps they should have just taken the gold and ran when they had the chance. In return, they must help the rebels fight against Hussein’s Elite Guard. Major Archie Gates (George Clooney), then set out to rescue their captive comrade with the help of a group of Iraqi rebels. Troy Barlow (Mark Wahlberg), is captured by Iraqi Intelligence. Problems arise, however, when one of them, Sgt. In the movie, four American soldiers decide to steal some of Saddam Hussein’s hidden gold, because, why not. We begin our list with Three Kings, a film set at the end of the Gulf War. Top 20 Treasure Hunting Movies: 20) Three Kings (1999) Below are the top twenty treasure hunting movies of all time…according to Queen City Escape. So we started thinking: what are some of the best treasure hunting movies? We compiled a list, ranking the films on both their popularity as well as how important treasure is to each film’s plot. When you throw a 230-pound Austrian mutant in your death arena, try not to look surprised when he rips your neck out through your ass and says some glib neck related pun to the camera.Since opening our latest escape room, the 7 Wonders of the World Adventure, we’ve been knee-deep in Carmen Sandiego and everything treasure hunting. Ha, no seriously, it's Arnold-he tears the place apart and ruins everyone's fucking day. Convicted of a crime he didn't boo-fucking-hoo, Arnold Schwarzenegger is forced to compete in this horrible game, and as you can imagine, is gruesomely killed. The Running Man People hunted for sport: CriminalsĪnother one set in a dystopic future, The Running Man focuses on a popular game show where contestants are expected to run and die. Also notable is the part of Frankenstein as played by David Carradine, whose recent probable-penis-related death makes enjoying this tale of butchery somewhat more bittersweet. Less awesome, but interesting is the presence of Sylvester Stallone, during that part of his career after he stopped doing porn, but before he did Rocky. Well, it's got men in costumes running down people in themed automobiles. Note: The Count (Distinct) aggregation is not supported for Microsoft Access data sources, and for Microsoft Excel and Text File data sources using the legacy connection. So the dimension actually takes on the characteristics of a measure. You aggregate a dimension, you create a new temporary measure column, You can aggregate a dimension in the view as Minimum, Maximum, Count, or Count (Distinct). You can change the aggregation for a measure in the view from its context menu: In Tableau, multidimensional data sources are supported only in Windows. Sources contain data that is already aggregated. You can view or change the default aggregation for a measure-see Set the Default Aggregation for a Measure. Every measure has a default aggregation which is set by Tableau when you connect to a data source. The current aggregation appears as part of the measure's name in the view. Sum, average, and median are common aggregations for a complete list, see List of Predefined Aggregations in Tableau. When you add a measure to the view, Tableau automaticallyĪggregates its values. Change the Aggregation of a Measure in the View Use your (Link opens in a new window) account to sign in. Watch a Video: To see related concepts demonstrated in Tableau, watch Aggregation, Granularity, and Ratio Calculations (Link opens in a new window), a 4-minute free training video. The type of aggregation applied varies depending on the context of the view. Whenever you add a measure to your view, an aggregation is applied to that measure by default. In Tableau, you can aggregate measures or dimensions, though it is more common to aggregate measures. The other Equifax marks used herein are trademarks of Equifax Inc.
Figuring the small size of the first save should get things running, I tried that. I read some forum posts that part of the problem is the ballooning size of the save file, among other suggestions. My current thought is the game may still be loading background stuff which causes a load glitch if I try and start the game before it is ready. New theory: I have noticed if I wait during the intro screens until the music comes in strong (all the horns and base sound) and then wait until shortly after the background switches, I seem to be loading any save game OK. It has also failed to load a couple of times even using the small save game to start. After the game starts, I open the Load menu again and load my current game. Infinite loading screen work around for me: I choose to load the first save game I ever made (in Goodsprings) which is a very small file. I guess its because of the changes that they have made with other games to make them more stable, that I expected the same treatment for this game. Naturally you can install other mods on top of these, assuming they're compatible - there are specific YUP patch-projects to ensure YUP can be used with other mods, and AFAIK the anti-crash fix is compatible with all other mods. Squid830: I realise it's probably not what you want to hear, but if you want to know the best way to get NV to work well. pretty much exactly as it was released (barring bug-fixes to those things). Note that installing only the above will ensure you can play NV with a minimum of crashes and other bugs, while keeping the core gameplay, mechanics, quests etc. Unfortunately I can't see GOG fixing this, unless of course by "fixing it" one means "comes pre-installed with the above" - which is possible, since they did it with Vampire: The Masquerade: Bloodlines (albeit that only required one patch). YUP : Fixes a vast array of bugs without changing content or gameplay (IMO this is essential) For me it still crashes occasionally, but nowhere near as often - and I can't remember if I even ever had the never-ending loading bug. New Vegas Anti Crash: This should stop most crashes. Fallout Mod Manager: For painless mod management. New Vegas Script Extender: Needed for a lot of mods, including some of the below. I highly recommend the following, irrespective of which version of NV you have (by that I mean, I consider them essential if you don't want to punch your monitor because the game crashed again or yet another quest got bugged so you can't complete it): I realise it's probably not what you want to hear, but if you want to know the best way to get NV to work well. they have to return the land to the original owner, and they won't, so i am sitting here laughing at the foolishness, but as that red descendant i know my place with god is good, for I made no lie against my brother. that's what the book promises, for they upheld not the Jubilees, because if they DID. US funds are created in their entirety in that fashion, by defrauding the native (red) children of this nation, and all nations have participated in that act and upheld an unjustifiable rule which amounts to enslavement (wrongful possession of a man) and murder, because of this act, for the sake of upholding non-rightful rule so that you can pilfer out internationally through "commerce".ĩ0% gone. This is to say that he will face 2 deaths. He who defraudeth the poor shall be counted as a man of blood. He who seeks profits in the debt of others will be removed soon. Revelations 12 coming to pass soon too, 100 days till that day, and a eclipse 1 month before.ġ Thessalonians chapter 5 refers to that day as "the day of the lord". Scales on those US dollars too, funny huh? When you see a scale, know Esau is at hand. God hated Esau, he cheated his brothers with his invention, the scale. but should you not expect your brother, who knows that the product is not fully correct, to be honest with you? You can't expcet GoG to spend thousands of hours decompiling binaries (which they probably aren't even allowed to do) and hopefully fix some obscure Gamebryo engine bug. If you want to be mad at someone, direct it at Bethesda. Then there are thousands of technical bugs which cannot be fixed by modders but only by Bethesda. There are thousands of bugs left in every TES and Fallout games which are fixed by modders. If you are new to After Effects and want to learn more about how to use this program, you should take this class. Explore animation basics and strategies.Practice importing data for your infographics.There are currently 11,828 students enrolled in this online class. The After Effects – Motion Graphics & Data Visualization course is available on Udemy and taught by Daniel Walter Scott, an Adobe Certified Instructor and Adobe Certified Expert. This class is unique because it focuses on teaching you to use After Effects for data visualization projects. Learning Adobe After Effects CC Tutorial VideosĪfter Effects CC 2019: Complete Course from Novice to ExpertĮxplore After Effects capabilities in order to enhance your skills and professional capabilities.After Effects for Beginners Complete Intro to After Effects. Introduction to Adobe After Effects: Getting Started with Motion Graphics.After Effects: The Complete Beginner Course (All Versions).After Effects – Motion Graphics & Data Visualization.After Effects CC Masterclass: Beginner to Advanced.Motion Graphics with Kurzgesagt – Part 1.After Effects CC 2019: Complete Course from Novice to Expert. For more information, visit my disclosure page. Our team chose these Adobe After Effects online programs based on different factors including difficulty level, instructor, price (free vs paid), duration and the number of students. So make sure you check out different After Effects course previews to find a good fit. Here are 8 After Effects courses, classes, programs and certificated to get you there. Become an After Effects expert this weekend. Examples of borrowing costs (rounded to the nearest cent) assuming that all charges are purchases bearing interest at the regular annual rate of 20.99%, a 30 day month, no charges made on special payment plans and no other fees, additional payments or other changes are: The Triangle Mastercard and the Triangle World Elite Mastercard do not have an annual fee. The billing period covered by each statement can be from 28-33 days. For residents of Quebec, the period between the statement date and the due date for payment is 26 days. The minimum payment is the sum of (a) the greater of: (i) interest and fees shown on your statement + $10 or (ii) 5% of the New Balance, excluding amounts on special payment plans, (b) any balance over your credit limit, (c) any amounts past due not included in (b) above, and (d) the amount of any equal payments plan instalments then due. Some applicants may receive a higher or lower regular annual rate depending on a credit evaluation. Offer subject to change without notice.Īdditional information for residents of Quebec only: The regular annual rate for persons applying for the Triangle Mastercard and the Triangle World Elite Mastercard is 22.99% for cash transactions and related fees and 20.99% for all other charges. Any unpaid portion not received by the due date will no longer form part of the equal payments plan and interest will accrue on that amount from the day after the date of your next statement at the applicable regular annual rate. Each month during an equal payments plan you are required to pay in full by the due date that month’s equal payments plan instalment. There is no administration fee charged for entering into a special payments plan. However, if we do not receive the full minimum due on a statement within 59 days of the date of that statement, or any event of default (other than a payment default) occurs under your Cardmember Agreement, all special payment plans on your account will terminate and (i) you will then be charged interest on the balances outstanding on such plans at the applicable regular annual rate from the day after the date of your next statement, and (ii) the balances outstanding will form part of the balance due on that statement. Interest does not accrue during the period of the plan. Dealers may sell for less.įinancing available is “Equal payments, no interest” for 24 months (unless otherwise stated) and is only available on request, on approved credit and on purchases of $150 (unless otherwise stated) or more (Gift Cards excluded) made with your Triangle credit card at Canadian Tire, Sport Chek, Mark’s, L’Équipeur, Atmosphere, Sports Rousseau, Hockey Experts, L’Entrepôt du Hockey and participating Sports Experts. **Online prices and sale effective dates may differ from those in-store and may vary by region. ±Was price reflects the last national regular price this product was sold for. The tire producer / manufacturer and Canadian Tire uses this fee to pay for the collection, transportation, and processing of used tires.ĬANADIAN TIRE® and the CANADIAN TIRE T riangle Design are registered trade-marks of Canadian Tire Corporation, Limited. EASY TO CLEAN: Includes nonstick cooking baskets and dishwasher-safe crisper plates.△The tire producer / manufacturer of the tires you are buying, and Canadian Tire is responsible for the recycling fee that is included in your invoice.chickens up to 30% faster than a traditional oven. XL ZONES: They have their own cooking baskets, cyclonic fans, and rapid heaters. CAPACITY AND 2 BASKETS: Cook a main and a side at the same time for quick, large family meals, or cook up to 8 -lbs. 6 VERSATILE COOKING PROGRAMS: Air Fry, Air Broil, Roast, Bake, Reheat, and Dehydrate.whole chicken and side as quickly as possible when Match Cook™ or Smart Finish™ is not selected. 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Also in this case, the mixing ratio is 1: 3 to 1: 5. In this preparation variant, however, great caution is necessary: If still burning pieces of sugar into the glass, it may well happen that also ignites the remaining absinthe. The sugar is added to the drink only after completion of this procedure. When the sugar begins to caramelize and bubbles, the flames are extinguished. Here are one to two pieces of sugar cubes, which were previously soaked in absinthe, placed on an absinthe spoon and lit. It was developed by a Czech absinthe producer in the 1990s to make the drink more attractive and saloon-friendly. The mixing ratio is in this preparation variant at 1: 3 to 1: 5.Ī high entertainment factor brings the Czech drinking with, which has no historical roots. One to two pieces of sugar are placed on a special Absinthe spoon and poured very gently with cold water. From the 19th century until its prohibition in the 20th century, the spirit was drunk in France with sugar. The French drinking ritual is the only one that has a historically proven tradition. All have in common that the absinthe in the ratio 1: 1 to 1: 5 diluted with ice water, the standard ratio is 1: 3. The best known are the Swiss drinking method, the French drinking ritual and the Czech fire ritual. Over time, different drinking styles and rituals have evolved from absinthe. The clear liquid gets a milky-cloudy color. In principle, absinthe, similar to the aniseed spirits Ouzo or Pastis, diluted with water consumed. Absinthe Preparation: So you drink it properly In the country of origin of Absinthe, Switzerland, the production and sale of the spirit was not allowed until 2005. When it emerged that the moderate enjoyment of the drink was by no means questionable, since 1998 absinthe has been reintroduced in most European countries. On the whole, however, the observed side effects are simply attributable to the high alcohol consumption. Methanol, which causes dizziness, headaches and can be fatal if overdosed, was formerly buried in absinthe. It was not uncommon for it to contain amyl alcohol and other fusel oils. Rather, the health damages that occurred at that time are due to the inferiority of the alcohol. As a result, in 1915, the production and consumption of the beverage was banned in the US and other European countries.ĭamage caused by absinthe consumption could not be proven in modern studies. Absinthe and its infamous storyĪs the consumption of absinthe finally boomed, the liquor came into disrepute because of its thujone content and to have negative health effects. Due to the bitter herbs used for production, such as wormwood, absinthe is referred to as bitter spirit, but it does not taste really bitter. The alcohol content is approximately between 45 and 85 percent by volume and therefore belongs to the harder alcohol segment. Since most Absinthmarken have a green color, the brew is often called La fée verte, to German The Green Fairy. Absinthe or in some countries called “vermouth spirits”, is an alcoholic beverage made from wormwood, fennel, anise and a number of other herbs. According to this view, affinity and efficacy are intrinsically linked for agonists, so it is impossible to obtain a value for the dissociation constant for an agonist that does not include some component of efficacy. It has, however, been stated that all estimates of agonist affinity are fundamentally flawed ( Colquhoun, 1998). Agonist dissociation constants are used in structure/activity studies for drug design, in providing estimates of agonist efficacy (see below) or in mutagenesis studies to examine how ligands and receptors interact. Alternatively, dissociation constants can be estimated using the receptor inactivation method of Furchgott ( Furchgott, 1966 Furchgott and Bursztyn, 1967) or the comparative method of Barlow et al. Agonist dissociation constants can be estimated using in vitro techniques such as ligand-binding assays, providing the assay conditions are carefully controlled (see below). In principle, it should be possible to obtain estimates of agonist affinity in terms of dissociation constants for the binding of ligands to their receptors. GPCRs are of great importance for drug action constituting more than 30% of current drug targets.ĭefining the affinity of agonists at their receptors I shall consider this problem for agonists at G protein-coupled receptors (GPCRs). If these measurements are inaccurate or inadequate, then this has great importance and, in this review, I wish to consider different ways in which affinity and efficacy can be measured. In basic biology studies of receptor structure and function, measurements of affinity and efficacy underpin analyses of ligand/receptor interaction in both SAR and mutagenesis analyses. In the past, this has mainly been in terms of affinity measurements but, more recently, measurements of ligand efficacy have become important ( Williams and Sewing, 2005). In drug discovery, these measurements guide the efforts of medicinal chemists. Accurate measurement of affinity and efficacy for ligands is very important for drug discovery and for basic biology. Agonists are said to have positive efficacy, inverse agonists are said to have negative efficacy and neutral antagonists have zero efficacy. This second attribute has been termed efficacy. Second, the ligand may have effects on the receptor and its associated signalling systems. First, the ligand must bind to the receptor it is said to have affinity for the receptor. The actions of ligands at receptors depend on two fundamental events. It is still, however, necessary to have accurate measures of efficacy in different pathways. The efficacy of a ligand may, therefore, be multidimensional. Considerable evidence now suggests that ligand efficacy may be dependent on the pathway used to assess it. Here I show that E max K obs/EC 50 provides the best assessment of efficacy for a range of agonists across the full range of efficacy for full to partial agonists. Efficacy can be quantitated in several ways based on functional data (maximal effect of the agonist ( E max), ratio of agonist dissociation constant to concentration of agonist giving half maximal effect in functional assay ( K obs/EC 50), a combined parameter E max K obs/EC 50). Also in pharmacological functional studies, good estimates of agonist dissociation constants are possible. Here I show that for many GPCRs, if receptor/G protein coupling is suppressed, experimental measurements of agonist affinity using ligand binding ( K obs) provide quite accurate measures of the agonist microscopic dissociation constant ( K A). It has, however, been suggested that measurements of affinity are always contaminated by efficacy so that it is impossible to separate the two parameters. Agonist affinity may be estimated in terms of the dissociation constant for agonist binding to a receptor using ligand binding or functional assays. In this review I wish to consider methods for measuring affinity and efficacy at G protein coupled receptors (GPCRs). Measurements of affinity and efficacy are fundamental for work on agonists both in drug discovery and in basic studies on receptors. There were also colleges and assisted living homes. During the busy season he said he could work on about three dozen a month. Mudge also tuned pianos on cruise ships in Boston and New York. “And do anywhere between five and seven pianos a day, six to seven days a week.” He could start at a high school – maybe in Wellesley or Brookline – then Mudge might head over to a private client, hit a recording studio, a church, maybe a hotel, “and then I'd usually end my day at one of the jazz clubs or both the jazz clubs,” he said. It would've been one of many stops in a typical work day for Mudge that often began at 6 a.m. Before the pandemic he made the trip from Hyde Park once or twice a week. Mudge hadn't tuned the gleaming Yamaha since December because there haven't been many sessions on Wellspring's books. She was on her way to record a video performance. (Jesse Costa/WBUR)Īt the studio Mudge worked to get the piano ready for Boston jazz pianist Yoko Miwa. Fred Mudge has tuned pianos everywhere from Fenway Park to local jazz clubs. His only performance tuning job was outdoors in October for a Wynton Marsalis show at the Yarmouth Drive-In. And if you get somebody that's really hitting hard it's going to throw the piano considerably out of tune.”īut Mudge hasn't set foot inside a music venue in more than a year. “They have four strings or six strings – I have 230. They're tuning in between pieces of music that they play,” he said. “The guitarist gets to tune in between songs. Mudge would hang back, at the ready, throughout Corea's performances – just in case. You can have a great piano not prepared well and it's a dog.” “You know the piano technician is like 80% of the piano. “I got a real nice piano, and a real good piano tuner, so we're good this week,” Corea told the audience. Since the early '90s he tuned for the late Chick Corea who praised Mudge during a show at Scullers Jazz Club. Over the years Mudge toted his tool kit to venues big, medium and small including TD Garden, Fenway Park, the House of Blues and the Berklee Performance Center. Also for piano legends like Billy Joel, Elton John, Stevie Wonder, Emanuel Ax and Dave Brubeck. Mudge has prepared instruments for concerts with big name musicians including Paul Simon, Aretha Franklin, Peter Gabriel, James Taylor, Carole King and the Red Hot Chili Peppers. “You get it close and you can always make it better.” Fred Mudge uses a tuning hammer to tune a Yamaha C7 piano. “As you can see it's a circle of refinement,” he explained while slowly moving from the low keys on the board to the high. A long strip of soft red felt muted the other tightly wound wires inside a black Yamaha grand until it was their turn for Mudge's adjustments. On the day we spoke Mudge was meticulously tweaking strings with his tuning hammer at Wellspring Sound Studio in Acton. “Three things throw a piano out of tune,” he explained. His name is Fred Mudge and he's been a piano technician, fulltime, for about three decades. Today we meet someone who's something of a barometer for the battered live music industry in Boston. This month we've been asking them about their experiences for our series “The Creative Grind.” (Jesse Costa/WBUR) This article is more than 2 years old.įrom performers to painters, artists of all genres have endured an economic year like no other. Fred Mudge uses a tuning hammer to tune a Yamaha C7 piano at the Wellspring Studio in Acton. |